World Osteoporosis Day 2007 Press Release Information
Osteoporosis is a condition associated with bone fragility and increased risk of bone fractures. This is one of most common and disabling illnesses that are associated with pain, loss of mobility and independency. Many patients died within one year of their fracture. About 1/3 of postmenopausal women and 1/10 of men above the age of 50 have osteoporosis. It is estimated that about 300,000 women and 100,000 men in Hong Kong are currently suffering from osteoporosis.
Although low BMD is used as for diagnosing osteoporosis, only half of the patients with fracture have BMD values below the diagnostic threshold. Risk factor assessment, in addition to BMD measurement, is increasingly recognized as a reliable predictor of absolute osteoporotic fracture risk. However, Asian-specific data on risk factors for osteoporosis remain sparse The University of Hong Kong had conducted a prospective study to determine the specific independent risk factors for osteoporotic fracture and to predict the 10-yr risk of fracture in the postmenopausal Southern Chinese population.
A total of 1435 community-dwelling, postmenopausal, treatment-naive women were recruited. Baseline demographic characteristics and clinical risk factors were obtained, and BMD at the spine and hip was measured. Subjects were followed for outcomes of low trauma fracture. Ten-year risk of osteoporotic fracture was predicted from the risk factor assessment and BMD measurement.
The mean age of subjects was 63 yr. After an average follow-up period of 5yr (range, 1.0-11.0 yr) of follow-up, 80 non-traumatic new fractures were reported. Eight independent clinical risk factors identified at baseline were found to be significant predictors of osteoporotic fracture, with the most important being use of walking aids (4.2-fold increased risk) and a history of fall (4-fold increased risk). Other predictive factors included being homebound, calcium intake < 400 mg/day, age > 65 yr, history of fracture, and BMI <
In conclusion, clinical risk factor assessment, in addition to BMD measurement, is a reliable predictor of 10-year risk of osteoporotic fracture.