Chinese Osteoporosis Screening Algorithm (COSA)
COSA is a risk prediction tool specifically designed for the Chinese population.
Background
Osteoporosis is a prevalent disease affecting hundred millions of people worldwide. We recently projected the hip fracture number in Asia and found that the number of hip fracture will be doubled by 2050 [1]. Thus, there is an urgent need to reduce the incidence of hip fracture, particularly in Asia.
1. Cheung C.L., Ang S.B., Chadha M., Chow E.S.-L., Chung Y.-S., Hew F.L., Jaisamrarn U., et al. An updated hip fracture projection in Asia: the Asian Federation of Osteoporosis Societies study. Osteoporos Sarcopenia. 2018;4:16–21.
Research Team
Objective
To enhance the public awareness and facilitate diagnosis of osteoporosis, we aim to develop a new Chinese Osteoporosis Screening Algorithm (COSA) to identify people at high risk of osteoporosis.
Methods
A total of 4747 postmenopausal women and men aged ≥ 50 from the Hong Kong Osteoporosis Study were randomly split into a development (N = 2373) and an internal validation cohort (N = 2374). An external validation cohort comprising 1876 community-dwelling subjects was used to evaluate the positive predictive value (PPV).
External Validation of COSA
